The Goldilocks Approach to Vaccines

9 October 2013 by Nathalia Holt, posted in Uncategorized

Last month, a study published by Louis Picker and his colleagues at Oregon Health & Sciences University generated a lot of excitement. The study tested a vaccine for SIV in monkeys already infected with the virus. After receiving the vaccine, 9 out of 16 monkeys cleared the infection. The NYTimes described it under the headline “New Hope for H.I.V. Vaccine.” This data builds on Picker's 2011 study that found 13 of 24 monkeys receiving the vaccine were protected from the virus. In a field mired in disappointment, many are excited about this unique approach to an HIV vaccine. However, Picker’s approach has the potential to influence more than HIV, it could change the way we think about vaccines.

 

Finding a virus that's just right

Finding a virus that's just right

 

On Tuesday, Louis Picker began his talk to a packed room at the AIDS Vaccine meeting in Barcelona, Spain with the line, “The trick to making a vaccine is to be humble and accept the fact that viruses are smarter than we are.”  He wasn’t referring just to HIV. Instead he was talking about CMV, or cytomegalovirus.

 

CMV is very clever.  A member of the herpes virus family, it’s over 200 million years old. This long evolution means that the virus has become adept in surviving within mammals. While the virus is found in roughly 45% of people, it rarely causes disease. Given its benign nature, Picker calls it “a parasite not a pathogen.” With these characteristics, perhaps it’s surprising that no one has attempted to use CMV in vaccines before now.

 

What makes Picker’s approach unique is not how it manipulates HIV. In fact, the parts of HIV used in his vaccine are far from exceptionable. The vaccine uses pieces of an HIV protein called gag, a group of proteins that make up the basic structure of the virus. The gag protein has been a component of many failed vaccine attempts. What makes this vaccine different is not the innards of HIV it contains but instead how these pieces are delivered.

 

Ineffective vehicles to deliver vaccines have hurt the HIV vaccine field. Just this past spring an HIV vaccine trial was halted because of delivery problems. The virus used in the halted trial, an adenovirus, wasn’t able to protect people from infection and may have been making those receiving it MORE susceptible to HIV. Whereas successful vaccines such as those for Polio are effective simply using either killed virus, or live, attenuated virus (a live virus that doesn’t cause disease), this approach doesn’t work for HIV. Something stronger is needed to clear HIV.

 

To create this something stronger, researchers have relied on viruses. Viruses are unbelievably good at stimulating the immune system, creating a horde of immune cells ready to ensnare and kill. But using viruses is tricky. After all, many cause disease. They first need to be engineered into empty shells, called vectors, capable of invading the immune system but unable to hurt their host. At the same time, we don’t want to make them so weak that they can’t engage with our immune system. They need to recognize HIV and kill it. But they shouldn’t produce such a powerful immune response that they overwhelm the body, potentially making it more vulnerable to pathogens.

 

So far HIV vaccines have tried poxviruses, which don’t yet seem to produce a strong enough immune response in humans.  On the opposite end of the spectrum, trials using adenoviruses seem to produce immune responses that are a little too strong. If preliminary results are correct, CMV may be just right. This is why Picker calls CMV the goldilocks vector. It seems to have hit that elusive sweet spot. It stimulates the immune system just enough to recognize and kill HIV but not so much that our entire immune system becomes exhausted and gives up.

 

This is exciting because it opens the door to a new way of thinking about vaccines, one focused on the immune system response instead of the pathogen itself. It may pave the way to vaccination for a variety of diseases that have been difficult to target. One of these is tuberculosis. Picker has found that the CMV vector is effective at protecting monkeys from TB. He presented data from a small, ongoing study where 5 out of 7 monkeys were protected from the bacterial disease after vaccination. Picker postulates that CMV vectors may be effective in a multitude of diseases including malaria and herpes. For now, the data using SIV is by far the most impressive. Of the 96 monkeys they’ve tested, 48 have been protected using the CMV vaccine.

 

The first question Picker received after his talk at the AIDS Vaccine conference was the most obvious one: “Why half?” Why are only half of the monkeys protected from infection? It’s a mysterious finding that Picker doesn’t have an answer to. Picker wonders if it could be related to the pathogenicity of the virus they’re testing. The SIV they’re challenging with is SIVmac239. It's a notorious virus that replicates to levels 100x higher than its human counterpart HIV. The fact that the vaccine is effective against SIVmac239 raises hope that it may work even better in humans against HIV. Picker says, “I don’t know if it will be 50% in humans. It may be 70% or it may not work at all.” There’s simply no way to know until it’s tested in people. Picker hopes to start human trials in 2016.

 

While it’s always nice to see an effective vaccine, it would be even better if we understood how it works. While we know that the vaccine increases virus-specific effector memory T-cells, the powerhouses that remember HIV and kill it, it’s not clear how it mobilizes them. In the words of Picker, “There is no immune response correlated with protection.” The T cell responses themselves are unconventional, recognizing both class I and class II MHC molecules. This means that multiple cell types may be triggering the immune response. Even more confusing, this immune response appears to be the same in both protected and unprotected monkeys receiving the vaccine.

 

On the practical side, we don’t know if CMV vectors are safe in humans. Picker and his team have now designed a new type of CMV vector that is missing a gene needed for replication. While this CMV can still spread, its growth is much slower. This new design should keep the virus from causing disease. However, the jury is still out on whether this engineered CMV will maintain that elusive balance between stimulating the immune system not too much but not too little. It has to be just right.

 

See the full talk at the AIDS Vaccine 2013 meeting:

http://www.aidsvaxwebcasts.org/console/player/21652?mediaType=audio&


41 Responses to “The Goldilocks Approach to Vaccines”

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  1. Martin Holzherr Reply | Permalink

    The Goldilocks approach means then to optimally stimulate the immune system while presenting the antigene.
    Perhaps a good term: Goldilocks approach. It remembers me of the Goldilock zone around a star. This Goldilocks zone where life can thrive is rather small. Too near to the sun and the most important ingredient for life - water - will cook, too far and water will freeze.

  2. Martin Holzherr Reply | Permalink

    "Picker’s approach has the potential to influence more than HIV, it could change the way we think about vaccines."

    Vaccines have indeed more potential applications than most of us consider to be possible.
    The article Understanding the science and the potential of cancer vaccines reports about the work of Dr. Claudia Grave, which uses vaccines again tumor-associated antigens. Again, the most important part of the vaccination seems to be how one delivers the antigen. "Dr. Gravekamp launches into a thorough description of her own research to make better cancer vaccines using Listeria, an intracellular bacterium that does not multiply in normal tissues but does infect tumor cell."

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  18. Claudy Reply | Permalink

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    Hello friends herpes has cure but doctor said herpes has no cure until i met Dr Suku who help me in my life. I was infected with Herpes Genital in 2008, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution,so that my body can be okay.until this faithful day as i was browsing the net I saw a testimony on how Dr.Suku helped people in curing HERPES disease, quickly I copied his Email which is (greatsukusolutiontemple@hotmail.com) so i contacted him for solution for my Herpes,so Dr Suku told me that his going to prepare herbal medicine for my health,then he prepared the medicine and luckily after two week my herpes was be cured.Dr Suku is well recognize as one of the best herbalist doctor in Africa, you don't have to be sad anymore or share your tears anymore on this disease when the cure have already be found by Dr.Suku herbal medicine,he so cure HIV,CANCER, ALS,HEPATITIS B, DIABETIC,contact him or call +2348074839242.

  20. Jeff Davis Reply | Permalink

    Hello friends herpes has cure but doctor said herpes has no cure until i met Dr Suku who help me in my life. I was infected with Herpes Genital in 2008, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution,so that my body can be okay.until this faithful day as i was browsing the net I saw a testimony on how Dr.Suku helped people in curing HERPES disease, quickly I copied his Email which is (greatsukusolutiontemple@hotmail.com) so i contacted him for solution for my Herpes,so Dr Suku told me that his going to prepare herbal medicine for my health,then he prepared the medicine and luckily after two week my herpes was be cured.Dr Suku is well recognize as one of the best herbalist doctor in Africa, you don't have to be sad anymore or share your tears anymore on this disease when the cure have already be found by Dr.Suku herbal medicine,he so cure HIV,CANCER, ALS,HEPATITIS B, DIABETIC,contact him or call +2348074839242.via website; http://greatsukusolutiont.wix.com/dr-suku

  21. sonia stevens Reply | Permalink

    I want to share this wonderful testimony to the people who are in the same problem that i was before i meant Dr Ben. i was living with HIV for the past 2 years, just last month as i was browsing on the internet about this deadly disease, i saw a testimony of somebody called Grace, testifying of how she was cured from HIV by Great Dr Ben and i decided to also email this man and tell him about my problem and as i did that, he told me to send him some of my personal details which i did and he prepared me a portion which i took and then he told me to wait for one week. After one week he told me to go for another HIV test, which i did and to my greatest suppress i was confirmed negative. all thanks be to Dr Ben and if you know that you are in this same problem email him now on( drbenharbalhome@gmail.com )

  22. Jeff Davis Reply | Permalink

    Hello friends herpes has cure but doctor said herpes has no cure until i met Dr Suku who help me in my life. I was infected with Herpes Genital in 2008, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution,so that my body can be okay.until this faithful day as i was browsing the net I saw a testimony on how Dr.Suku helped people in curing HERPES disease, quickly I copied his Email which is (greatsukusolutiontemple@hotmail.com) so i contacted him for solution for my Herpes,so Dr Suku told me that his going to prepare herbal medicine for my health,then he prepared the medicine and luckily after two week my herpes was be cured.Dr Suku is well recognize as one of the best herbalist doctor in Africa, you don't have to be sad anymore or share your tears anymore on this disease when the cure have already be found by Dr.Suku herbal medicine,he so cure HIV,CANCER, ALS,HEPATITIS B, DIABETIC,contact him or call +2348074839242....

  23. Jeff Davis Reply | Permalink

    Hello friends herpes has cure but doctor said herpes has no cure until i met Dr Suku who help me in my life. I was infected with Herpes Genital in 2008, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution,so that my body can be okay.until this faithful day as i was browsing the net I saw a testimony on how Dr.Suku helped people in curing HERPES disease, quickly I copied his Email which is (greatsukusolutiontemple@hotmail.com) so i contacted him for solution for my Herpes,so Dr Suku told me that his going to prepare herbal medicine for my health,then he prepared the medicine and luckily after two week my herpes was be cured.Dr Suku is well recognize as one of the best herbalist doctor in Africa, you don't have to be sad anymore or share your tears anymore on this disease when the cure have already be found by Dr.Suku herbal medicine,he so cure HIV,CANCER, ALS,HEPATITIS B, DIABETIC,contact him or call +2348074839242......

  24. smith brandy Reply | Permalink

    Good day to you all friends, my name is Smith Brandy from United State,I have been suffering from (HERPES) disease for the last four years and had constant pains, especially in my knees. During the first year,I had faith in God that i would be healed someday. This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came searching on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been cured of genital herpes by this Man Dr Agbaka and she also gave the email address of this man and advise me to contact him for any sickness that he would be of help, so i wrote to Dr Agbaka telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as Dr Agbaka assured me, after some time i went to my doctor to confirm if i have be finally cured, behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr Agbaka on : (agbakaherbalhome@gmail.com) or call and watsapp him with +2348077126783.. THESE ARE THE THINGS DR AGBAKA CAN ALSO CURE: GENITAL WARTS, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, STROKE, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!!!

  25. smith brandy Reply | Permalink

    Good day to you all friends, my name is Smith Brandy from United State,I have been suffering from (HERPES) disease for the last four years and had constant pains, especially in my knees. During the first year,I had faith in God that i would be healed someday. This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came searching on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been cured of genital herpes by this Man Dr Agbaka and she also gave the email address of this man and advise me to contact him for any sickness that he would be of help, so i wrote to Dr Agbaka telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man, few weeks later i started experiencing changes all over me as Dr Agbaka assured me, after some time i went to my doctor to confirm if i have be finally cured, behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr Agbaka on : (agbakaherbalhome@gmail.com) or call and watsapp him with +2348077126783.. THESE ARE THE THINGS DR AGBAKA CAN ALSO CURE: GENITAL WARTS, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, STROKE, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!

  26. Luz Giraldo Reply | Permalink

    Hello!!I am Luz Giraldo I’m indeed very happy for the great help that Dr.Oduma rendered to me, I am here to give my testimony about a doctor who helped me in my life. I and my Wife was infected with HERPES SIMPLEX VIRUS last 4 years ago, we went to many hospitals for cure but there was no solution, on till one faithful day , we saw a blog whereby Dr. Oduma cured a woman who also had herpes infection,we (Me and My Husband) decided to contact him which we did, he asked us to buy some items, unfailingly we sent him the money he will need in buying the items required , He caste the spell and asked us to go for check-up after three days of casting the spell, Luckily for us we were tested herpes negative, now I believe all these Testimonies about him on the internet, he is truly a great man, if you are going through the same problem and you need help you can contact the great Herbalist and a spell caster on (drodumaherbaltemple@gmail.com) ..or calling number +2348071622572..You can also view He is a good man

  27. Veronica Noah Reply | Permalink

    I want to tell the world Dr Ofemo have cure my HERPES VIRUS,for like 8 years Now I have been in pain suffering from HERPES VIRUS,but one day as I was surfing through the Internet i came across testimony in the internet on how Dr Ofemo Cure herpes patient and HIV/AIDS patient,I decided to give it a try to see if he could cure my herpes,and i follow the instruction he gave to me, to my greatest surprise after 2 week i was free from my herpes. I'm now here to testify that am No more a herpes patient, and now am so much happy,a great herbalist that treats and cure all manner of diseases like, HEPATITIS B CURE OR CANCER OR HIV&AIDS contact him now.drofemospelltemple@gmail.com to get your miraculous Herbal cured.his email via drofemospelltemple@yahoo.com or or cell number +2348163387496 thank you Dr Ofemo your herbal medicine is a powerful herbs for saving the world herpes disease.all thank to you Sir Ofemo.

  28. David Reply | Permalink

    Dr. khumalo God will continue to bless you more abundantly, for the good works you are doing in peoples life, I will keep on writing and posting testimonies about you on the Internet, I’m faith Stacey, I was a HBsag patient, I saw a blog on how Dr. Khumalo cured someone, I contacted him and also got my healing, kindly email him now on healthmedlab@gmail.com THESE ARE THE THINGS Dr. Khumalo DO. HERPES, WITCH CRAFT PROBLEM,HIV/AIDS. CANCER. ALS Hepatitis B/C .NEED YOUR EX BACK, PERFECT CHARM, NEED A BABY, thank you and God bless you for saving my life healthmedlab@gmail.com

  29. sov Reply | Permalink

    Hello to all my sisters. I am now 35 years old. I first found out I was HIV positive in 2015. This happened after the man I love became extremely sick. At first when I found out, I reacted just like anyone else. I thought my life was over. My mother was saddened by the news. I was scared to tell anyone. I fell hard into depression. I drank, smoked weed and was just slowly killing myself, Well to make this long story short. My Name is dobrovolska svitlana , My life is Back to me and God have be Good to me in life,before people said there is no cure on HIV/AIDS but today many people have now believe that there is a cure. HIV/AIDS can be cured through Africans roots and harms,and days our great doctors have finally found the cure of HIV/AIDS, many have gotten cured with the help of a great spell caster known as Dr oniha he is the one of the great spell doctor in Africa and he has the cure on this disease HIV/AIDS. last month he share is Haber medicine in some medical hospital and now he is well recognize as one of the best spell caster in Africa, you don’t have to be sad any more or share your tears any more on this disease when the cure have already be found. email;him with this address dronihaspell@yahoo.com or +2349059942347 So do you need a help to be cured from HIV from your body if yes email Dr oniha for your herbal medicine,he can be of help to you.

  30. Patrick allen rinn Reply | Permalink

    I ,am from united states of america, I want to testify of how i got cured of HIV, I got infected with HIV disease in 2010, visited several herbalists, spiritualists and pastors for cure but all to no avail, my world was gradually coming to an end until,i searched google and read about possible cures to get cured of hiv. i saw a post in a health forum about a herbal spell home,ACHIEVERS HERBAL TEMPLE,A temple that cures all kinds of deadly diseases including HIV AIDS, ALS, MND, Epilepsy, Leukemia, Asthma, Cancer, Ghonorhea etc, at first i got shocked,but when i read the temple's name again i thought of giving them a try because i so much believe in achieving what you desire. when i contacted this herbal spell home via email,he prepared a herbal spell portion and sent it to me via courier service, when i received this herbal spell portion, he gave me step by step instructions on how to apply them, when i applied it as instructed, i was cured of this deadly disease within 7days, I am now HIV Negative (-) all thanks to Achievers temple . Contact this great herbal spell home, Email: achieversherbaltemple@gmail.com or call 234 705 907 4351 Goodluck.

  31. Carol Micheal Reply | Permalink

    i was suffering from HIV/AIDS disease for the past 6 years ago and ever since i have been passing through serious agony in my life,i contact this infection through my boyfriend and i have done series of tests and taking drugs to be cure but unfortunate for me i still carry this deadly infection inside of me,i will love to say i was so lucky to have came across DR SUKU several testimony online people testifying series of how they were totally cure of HIV/AIDS through his herbal medicine on his email: greatsukusolutiontemple@hotmail.com i contacted his email and explain my situation to him and he accepted to help me cure my HIV/AIDS disease,i followed his instruction and indeed he prepare a herbal medicine for me and after i receive the herbal medicine he told me how to apply the herbal medicine and after 2 weeks of usage i did the test again and i was confirmed negative. you can contact his website: http://greatsukusolutiont.wix.com/dr-suku or his Mobil number +2348074839242..

  32. Williams Donald Reply | Permalink

    I want to appreciate Dr Suku for using his herbal medicine to cure my family herpes virus,since 3years ago my family have been having this herpes disease and it have been giving my family challenges,we were so perplexed cause my family have taken several drugs to be cure but every of our effort was in-vain,a fateful morning i was browsing through the internet then i saw several testimonies about Dr Suku curing people of their herpes disease immediately i contacted Dr Suku on his email:greatsukusolutiontemple@hotmail.com,told him about my family troubles and he told me that my family must be cure,so he prepare a herbal medicine for my family which we use for 2 weeks and everything was like a dream for my family,my family herpes disease was totally gone,why don't you contact him today and be free from your disease,his Mobile:+2348074839242 or his website:http://greatsukusolutiont.wix.com/dr-suku

  33. Seiders Gary Lee Reply | Permalink

    When I was 26 years old, I learned my HBsAg was reactive when I was required to undergo medical exam for an employment (so depressed I wasn't hired and the doctor had to write in big words, 'not fit to work' on my medical result clearance). It was my first time to be tested with that kind of blood work, so I have no idea when I contacted hepatitis B virus. My husband and I are the only ones who knew about my situation. I am so embarrassed and ashamed because hepatitis B is considered as an STD, like the infamous AIDS/HIV. My husband has no hepatitis B (thankfully) but I fear that even with his hepatitis B vaccine, he will get my disease, though doctors assures us he is safe from me.I always sleep longer than usual on weekends, always tired, often experiences tummy ache, sometimes unexpected skin itchiness/rashes, arthritis, irregular bowel movement and am temperamental But today am totally cure with the help of this clinic i came across on this web FORUM, the clinic name (HEALTH MED LAB) here is their email CONTACT THEM IF YOU ARE diagnosed OF HEPATITIS B VIRUS or any other sickness healthmedlab@gmail.com

  34. mark david Reply | Permalink

    All thanks to Dr voodoo my name is Mark David from united kingdom I am here to share a good testimony of my self on how i came in contact with a real herbalist who helped me. i appreciate everyone for taken their precious time to read my testimony, 6 months ago i was diagnosed of HERPES, this means that 6 months ago i was HERPES positive when i told one of my good friend about this, she sympathized with me and then she said that she was going to help me out, she told me that we should do some research on the Internet, we came across Dr voodoo and my friend said that she has come across a lot about him and said that he is a real herbalist remedy to all illness, i was really surprised on this and confused as well, I was so speechless and quickly i contact him to help me and he prepared some herbs for me and send it across to me and he told me the way i was going to be taken the medicine which i did, and in the next 2 weeks i went to the hospital and they
    said that i am now HERPES negative, i am very happy about this, when i contacted Dr voodoo again to tell him the good result , i asked him how he was able to help me, and he said that he was gifted with it that he can cure any disease. also reach him too because health is better than wealth Email him via"voodoospelltemple66@gmail.com or you can also add him on whatsApp +2348067101348

  35. jaz walker Reply | Permalink

    MY HIV HEALING TESTIMONY

    My mouth is short of words, i am so happy because Dr voodoo has healed me from HIV ailment which i have been suffering from the past 5years now, i have spend a lot when getting drugs from the hospital to keep me healthy, i have tried all means in life to always i can become HIV negative one day, but there was no answer until i found Dr voodoo the parish of African who provide me some healing spell that he uses to help me, now i am glad telling everyone that i am now HIV Negative, i am very happy, thank you Dr voodoo for helping my life comes back newly without any form of crisis, may the good lord that i serve blessed you Dr voodoo and equip you to the higher grade for healing my life. i am so amazed. so i will announced to everyone in this whole world that is HIV positive to please follow my advice and get healed on time, because we all knows that HIV disease is a deadly type,contact Dr voodoo for your HIV healing spell today at: voodoospelltemple66@gmail.com He will be always happy to assist you online and ensure you get healed on time, contact Dr voodoo today for your healing spell immediately, you can also add him on whatsApp +2348067101348 thank you sir.

  36. Isabela Santos Reply | Permalink

    My name is Isabela Santos, want to use this golden opportunity of mine to say thanks to Dr Boadi for curing my HIV VIRUS with his Herbal Medicine. i have been suffering from HIV this Virus for four years now, Is was a Miracle that i got Cured after Using Dr Boadi herbal medicine. For any Contact, visit Dr Boadi website: http://www.drboadiherbalcentre.webs.com if you are having a similar problem add dr Boadi on Whatsapp:+2348156769001 or contact him via email: drboadiherbalcentre@yahoo.com

  37. cythia morgan Reply | Permalink

    I am from Texas, I want to tell the world how I got cured from herpes simplex virus using the Dr Silver herbal drug. Naturally, I didn't believe that herpes is curable Until I came in contact with this man, he proved to me that herpes is curable and after using His herbal drug, i became cured!! This is indeed a surprise to me and I am happy for the wonderful work. For contact, here is His email: drsilverhealingtemple@gmail.com Thanks and God bless you all

  38. Krista Persin Reply | Permalink

    MY HIV CURE TESTIMONY
    My mouth is short of words, I feel very happy because Dr. JOKOTA has healed me from HIV disease who have been suffering for the last six [6] years, I spent almost all my savings in order to obtain some drugs the hospital just to stay healthy, I have made every effort to see if I can get rid of the deadly disease in my body system, but no way, so I thought that's how it'll end, not until a day i was reading some articles on the net, so I found a witness that a lady shared, at first I never thought so something came to my mind that I should give it a try I did and that's how I get on contact Dr. JOKOTA the Paris of Africa, explained everything to him as I have written, to cut shot, I provide some healing spell you use to help others, and asked me to use them in five [ 5] days, and the sixth [6] days I go for my check ....... who is lucky enough to read this, I think I'm the happiest woman. I will not go further, which may also need this help should contact Dr. JOKOTA for any assistance you may need. because this man is supernatural and confidence about the history of peoples. I'll write your contacts for anyone to relieve you also can reach for help,
    contact .... DRJOKOTASOLUTIONHOME@HOTMAIL.COM OR
    DRJOKOTASOLUTIONHOME@GMAIL.COM
    Thanks and Remain Bless

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