Musings on Mucopolysaccharides, Mechanobiology and Eponyms

Posted 17 July 2012 by Lowell Goldsmith - JID Jottings

Mucopolysaccharides (MPS; an older term), comprise a heterogeneous group of extracellular molecules, each consisting of a core protein(a proteoglycan) with covalently joined linear carbohydrates(a glycosaminoglycan). These molecules are important biomarkers and probes for exploring disease mechanisms. At the VIII Dermatology International Congress in Copenhagen of 1930, Heinrich Adolf Gottron reported increased metachromatic staining in Dermatomyositis (DM) skin lesions. Gradually, the clinical literature has come to use Gottron’s papules (GP), red to violet plaques over the metacarpalphalangeal distal, and proximal interphalangeal... Read more