adult stem cells

 

Builders and Blocks – Engineering Blood Vessels with Stem Cells

Posted 17 September 2014 by Jalees Rehman

Back in 2001, when we first began studying how regenerative cells (stem cells or more mature progenitor cells) enhance blood vessel growth, our group as well as many of our colleagues focused on one specific type of blood vessel: arteries. Arteries are responsible for supplying oxygen to all organs and tissues of the body and arteries are more likely to develop gradual plaque build-up (atherosclerosis) than veins or networks of smaller blood vessels (capillaries). Once the amount of plaque in... Read more

Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy

Posted 22 July 2014 by Jalees Rehman

[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... Read more

The Road to Bad Science Is Paved with Obedience and Secrecy

Posted 8 July 2014 by Jalees Rehman

We often laud intellectual diversity of a scientific research group because we hope that the multitude of opinions can help point out flaws and improve the quality of research long before it is finalized and written up as a manuscript. The recent events surrounding the research in one of the world's most famous stem cell research laboratories at Harvard shows us the disastrous effects of suppressing diverse and dissenting opinions. The infamous "Orlic paper" was a landmark research article published in... Read more

To Err Is Human, To Study Errors Is Science

Posted 21 May 2014 by Jalees Rehman

The family of cholesterol lowering drugs known as 'statins' are among the most widely prescribed medications for patients with cardiovascular disease. Large-scale clinical studies have repeatedly shown that statins can significantly lower cholesterol levels and the risk of future heart attacks, especially in patients who have already been diagnosed with cardiovascular disease. A more contentious issue is the use of statins in individuals who have no history of heart attacks, strokes or blockages in their blood vessels. Instead of waiting... Read more

Does Human Fat Contain Stem Cells?

Posted 30 April 2014 by Jalees Rehman

Aeon Magazine recently published my longform essay on our research with human liposuction samples and our attempts to use fat for regenerative and therapeutic purposes. Many research groups, including our own group, have been able to isolate stem cells from human fat. However, when it came to using this cells for treating cardiovascular disease, the cells behaved in a manner that we had not anticipated. We were unable to convert them into heart muscle cells or blood vessel endothelial cells,... Read more

The Largest Cell Therapy Trial in Heart Attack Patients Uses Hardly Any Stem Cells

Posted 28 February 2014 by Jalees Rehman

One of the world’s largest clinical cell therapy trials has begun to enroll 3,000 heart attack patients, some of whom will have bone marrow cells extracted with a needle from their hip and fed into their heart using a catheter in their coronary arteries. The BAMI trial has €5.9m in funding from the European Commission and will be conducted in ten European countries. Enlisted patients will be randomly assigned into two groups: one group will receive the standard care given... Read more

Stem Cells and Their Fat Neighbors

Posted 19 November 2013 by Jalees Rehman

We recently published a PLOS ONE paper (Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells) in which we studied how the metabolism of an adult stem cell can influence its ability to differentiate. Human bone marrow mesenchymal stem cells (also known as marrow stromal cells, marrow progenitor cells or MSCs) can be converted into fat (adipocytes), cartilage (chondrocytes) or bone (osteoblasts). The work performed by Yanmin Zhang and Glenn Marsboom in my lab showed that MSCs undergo a... Read more

Replicability of High-Impact Papers in Stem Cell Research

Posted 23 July 2013 by Jalees Rehman

I recently used the Web of Science database to generate a list of the most highly cited papers in stem cell research. As of July 2013, the search for original research articles which use the key word "stem cells" resulted in the following list of the ten most widely cited papers to date:   1. Pittenger M et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147 Citations: 8,157   2.  Thomson JA et al. (1998) Embryonic... Read more

Bone Marrow Cell Infusions Do NOT Improve Cardiac Function After Heart Attack

Posted 18 April 2013 by Jalees Rehman

For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks. It involves multiple invasive procedures in patients who are already quite ill, because they are experiencing a major heart attack: 1) Patients with a major heart attack (also referred to as ST-elevation Myocardial Infarction or... Read more

Are Scientists Divided Over Divining Rods?

Posted 25 February 2013 by Jalees Rehman

When I read a statement which starts with "Scientists are divided over......", I expect to learn about a scientific controversy involving scientists who offer distinct interpretations or analyses of published scientific data. This is not uncommon in stem cell biology. For example, scientists disagree about the differentiation capacity of adult bone marrow stem cells. Some scientists are convinced that these adult stem cells have a broad differentiation capacity and that a significant proportion can turn into heart cells or brain... Read more