stem cells

 

Lab Grown Organs and Artistic Computers in Fifty Years?

Posted 17 April 2014 by Jalees Rehman

The Pew Research Center released the 2014 survey of U.S. adults (1,001 participants, surveyed by land-line or cell phone interviews) regarding their views on technological advancements in the next 50 years. Over eighty percent of the participants said that "People in need of an organ transplant will have new organs custom made for them in a lab" and roughly half of the participants felt that "Computers will be as effective as people at creating important works of art such as... Read more

The Largest Cell Therapy Trial in Heart Attack Patients Uses Hardly Any Stem Cells

Posted 28 February 2014 by Jalees Rehman

One of the world’s largest clinical cell therapy trials has begun to enroll 3,000 heart attack patients, some of whom will have bone marrow cells extracted with a needle from their hip and fed into their heart using a catheter in their coronary arteries. The BAMI trial has €5.9m in funding from the European Commission and will be conducted in ten European countries. Enlisted patients will be randomly assigned into two groups: one group will receive the standard care given... Read more

Growing Skepticism about the Stem Cell Acid Trip

Posted 20 February 2014 by Jalees Rehman

In January 2014, the two papers “Stimulus-triggered fate conversion of somatic cells into pluripotency” and “Bidirectional developmental potential in reprogrammed cells with acquired pluripotency” published in the journal Nature by Haruko Obokata and colleagues took the world of stem cell research by surprise. Since Shinya Yamanaka’s landmark discovery that adult skin cells could be reprogrammed into embryonic-like induced pluripotent stem cells (iPSCs) by introducing selected embryonic genes into adult cells, laboratories all over the world have been using modifications of... Read more

Stem Cells and Their Fat Neighbors

Posted 19 November 2013 by Jalees Rehman

We recently published a PLOS ONE paper (Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells) in which we studied how the metabolism of an adult stem cell can influence its ability to differentiate. Human bone marrow mesenchymal stem cells (also known as marrow stromal cells, marrow progenitor cells or MSCs) can be converted into fat (adipocytes), cartilage (chondrocytes) or bone (osteoblasts). The work performed by Yanmin Zhang and Glenn Marsboom in my lab showed that MSCs undergo a... Read more

Replicability of High-Impact Papers in Stem Cell Research

Posted 23 July 2013 by Jalees Rehman

I recently used the Web of Science database to generate a list of the most highly cited papers in stem cell research. As of July 2013, the search for original research articles which use the key word "stem cells" resulted in the following list of the ten most widely cited papers to date:   1. Pittenger M et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147 Citations: 8,157   2.  Thomson JA et al. (1998) Embryonic... Read more

Cellular Alchemy: Converting Fibroblasts Into Heart Cells

Posted 11 May 2013 by Jalees Rehman

Medieval alchemists devoted their lives to the pursuit of the infamous Philosopher's Stone, an elusive substance that was thought to convert base metals into valuable gold. Needless to say, nobody ever discovered the Philosopher’s Stone. Well, perhaps some alchemist did get lucky but was wise enough to keep the discovery secret. Instead of publishing the discovery and receiving the Nobel Prize for Alchemy, the lucky alchemist probably just walked around in junkyards, surreptitiously collected scraps of metal and brought them... Read more

Bone Marrow Cell Infusions Do NOT Improve Cardiac Function After Heart Attack

Posted 18 April 2013 by Jalees Rehman

For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks. It involves multiple invasive procedures in patients who are already quite ill, because they are experiencing a major heart attack: 1) Patients with a major heart attack (also referred to as ST-elevation Myocardial Infarction or... Read more

Stemming the Flow: Using Stem Cells To Treat Urinary Bladder Dysfunction

Posted 19 February 2013 by Jalees Rehman

Neurogenic bladder is a disorder which occurs in spinal cord diseases such as spina bifida and is characterized by an inability of the nervous system to properly control the urinary bladder and the muscle tissue contained in the bladder wall. This can lead to spasms and a build-up of pressure in the bladder, often resulting in urinary incontinence. Children with spina bifida and neurogenic bladder often feel urges to urinate after drinking comparatively small amounts of liquid and they can... Read more

To Branch, Or Not To Branch – Plant Hormones Help Turn A Stem Into A Bush

Posted 31 January 2013 by Jalees Rehman

When we hear the expression "stem cells", we tend to think of cells from animals or patients that are used to treat diseases or promote regeneration. However, stem cells are also present in plants. The growing tips of plants are called meristems and they are reservoirs of plant stem cells. A meristem is formed at the base of each leaf and can remain dormant as a small bud or be activated and give rise to a whole new branch. Gardeners... Read more

Radical Tails: Antioxidants Can Prevent Regeneration

Posted 14 January 2013 by Jalees Rehman

Amphibians such as frogs or salamanders have a remarkable ability to regenerate amputated limbs and tails. The regenerative process involves the formation of endogenous pluripotent stem cells, which then expand and differentiate into the tissue types that give rise to the regenerated body part. The complex interplay of the cell types and signals involved in this regenerative response to the injury are not fully known and there is considerable interest in identifying all the necessary steps. The ultimate hope is... Read more