stem cells

Cellular Alchemy: Converting Fibroblasts Into Heart Cells

Posted 11 May 2013 by Jalees Rehman

Medieval alchemists devoted their lives to the pursuit of the infamous Philosopher's Stone, an elusive substance that was thought to convert base metals into valuable gold. Needless to say, nobody ever discovered the Philosopher’s Stone. Well, perhaps some alchemist did get lucky but was wise enough to keep the discovery secret. Instead of publishing the discovery and receiving the Nobel Prize for Alchemy, the lucky alchemist probably just walked around in junkyards, surreptitiously collected scraps of metal and brought them... Read more

Posted in cardiovascular, differentiation, gene expression, genome, heart disease, induced Pluripotent stem cells, iPSCs, molecular biology, regeneration, regenerative medicine, reprogramming, Stem Cells, wound healing |

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Bone Marrow Cell Infusions Do NOT Improve Cardiac Function After Heart Attack

Posted 18 April 2013 by Jalees Rehman

For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks. It involves multiple invasive procedures in patients who are already quite ill, because they are experiencing a major heart attack: 1) Patients with a major heart attack (also referred to as ST-elevation Myocardial Infarction or... Read more

Posted in adult stem cells, cardiovascular, heart disease, regeneration, regenerative medicine, research, Stem Cells |

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Stemming the Flow: Using Stem Cells To Treat Urinary Bladder Dysfunction

Posted 19 February 2013 by Jalees Rehman

Neurogenic bladder is a disorder which occurs in spinal cord diseases such as spina bifida and is characterized by an inability of the nervous system to properly control the urinary bladder and the muscle tissue contained in the bladder wall. This can lead to spasms and a build-up of pressure in the bladder, often resulting in urinary incontinence. Children with spina bifida and neurogenic bladder often feel urges to urinate after drinking comparatively small amounts of liquid and they can... Read more

Posted in adult stem cells, induced Pluripotent stem cells, iPSCs, mesenchymal stem cells, MSCs, patients, regenerative medicine, Stem Cells |

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To Branch, Or Not To Branch – Plant Hormones Help Turn A Stem Into A Bush

Posted 31 January 2013 by Jalees Rehman

When we hear the expression "stem cells", we tend to think of cells from animals or patients that are used to treat diseases or promote regeneration. However, stem cells are also present in plants. The growing tips of plants are called meristems and they are reservoirs of plant stem cells. A meristem is formed at the base of each leaf and can remain dormant as a small bud or be activated and give rise to a whole new branch. Gardeners... Read more

Posted in differentiation, plants, Stem Cells |

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Radical Tails: Antioxidants Can Prevent Regeneration

Posted 14 January 2013 by Jalees Rehman

Amphibians such as frogs or salamanders have a remarkable ability to regenerate amputated limbs and tails. The regenerative process involves the formation of endogenous pluripotent stem cells, which then expand and differentiate into the tissue types that give rise to the regenerated body part. The complex interplay of the cell types and signals involved in this regenerative response to the injury are not fully known and there is considerable interest in identifying all the necessary steps. The ultimate hope is... Read more

Posted in adult stem cells, antioxidants, oxidants, reactive oxygen species, regeneration, regenerative medicine, Stem Cells, wound healing |

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Immune Cells Can Remember Past Lives

Posted 9 January 2013 by Jalees Rehman

The generation of induced pluripotent stem cells (iPSCs) is one of the most fascinating discoveries in the history of stem cell biology. John Gurdon and Shinya Yamanaka received the 2012 Nobel Prize for showing that adult cells could be induced to become embryonic-like stem cells (iPSCs). Many stem cell laboratories now routinely convert skin cells or blood cells from an adult patient into iPSCs. The stem cell properties of the generated iPSCs then allow researchers to convert them into a... Read more

Posted in aging, cancer, cell biology, hiv, immunology, induced Pluripotent stem cells, lymphocytes, medicine, molecular biology, senescence, Stem Cells |

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Inspired By Snake Venom

Posted 1 January 2013 by Jalees Rehman

When I remember the 80s, I think of Nena’s 99 Luftballons, Duran Duran’s Wild Boys and ….snake venom. Back in those days, I used to be a typical high school science nerd. My science nerdiness interfered with my ability to socialize with non-nerds and it was characterized by an unnecessary desire to read science books and articles that I did not really understand, just so that I could show off with some fancy science terminology. I did not have much... Read more

Posted in cell biology, education, growth factors, history, induced Pluripotent stem cells, personal, research, science writing, scientific method, scientific methodology, Stem Cells |

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Can The Heart Regenerate Itself After A Heart Attack?

Posted 5 December 2012 by Jalees Rehman

Some cardiovascular researchers believe that the heart contains cardiac stem cells or progenitor cells which can become mature cardiomyocytes (beating heart cells) following an injury and regenerate the damaged heart. The paper "Mammalian heart renewal by pre-existing cardiomyocytes" published in the journal Nature by Senyo and colleagues (online publication on December 5, 2012), on the other hand, suggests that the endogenous regenerative potential of the adult heart is very limited. The researchers studied the regeneration of cardiomyocytes in mice using... Read more

Posted in adult stem cells, cardiovascular, cell biology, gene expression, heart disease, molecular biology, regenerative medicine |

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The Healing Power of Sweat Glands

Posted 20 November 2012 by Jalees Rehman

Two kinds of sweat glands are present in the human body. Apocrine sweat glands are located in arm-pits or rectogenital areas and are responsible for "smelly" sweat. Eccrine sweat glands, on the other hand, are distributed all over the human body and produce a non-odorous sweat. The eccrine sweat glands are primarily found in humans and certain primates. They also exist in some other mammals, but are usually restricted to the footpads of non-primate mammals. There is some controversy about... Read more

Posted in regenerative medicine, Stem Cells, wound healing |

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Somatic Mosaicism: Genetic Differences Between Individual Cells

Posted 19 November 2012 by Jalees Rehman

The cells in the body of a healthy person all have the same DNA, right? Not really! It has been known for quite some time now that there are genetic differences between cells within one person. The expression to describe these between-cell differences is "somatic mosaicism", because cells can represent a mosaic of genetic profiles, even within a single organ. During embryonic development, all cells are derived from one fertilized egg and ought to be genetically identical. However, during every... Read more

Posted in gene expression, genome, induced Pluripotent stem cells, molecular biology, Stem Cells |

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