The Rise and Fall of the Boston Patients

8 December 2013 by Nathalia Holt, posted in Uncategorized

A little over a year ago I first wrote about the Boston patients. These two men took us on an unusual journey this year. It began in 2010 when Timothy Henrich, then a fellow at Brigham and Women’s Hospital, was looking for a new research project. What he stumbled onto was a novel way of pursuing a cure for HIV. This week we learned that two men who were once considered as nearing a cure are actually not. Although it seems like this news should be a disappointing blow to the HIV research field, it actually gives us new insight into how to fight the virus.


Timothy Henrich was inspired by the story of Timothy Ray Brown. Timothy, suffering from acute myeloid leukemia, received a novel therapy that treated both his cancer and his HIV infection. He received two bone marrow transplants from a donor who was naturally resistant to HIV. This donor was resistant to HIV thanks to a mutation called CCR5Δ32. The CCR5 gene is almost always necessary for HIV to enter human cells. People missing 32 tiny bits of the gene have natural resistance to HIV because the virus can’t enter their cells.


Timothy received mutant cells that went on to make a brand new immune system in his body. This new immune system was one that HIV couldn’t invade. Stopping antiviral therapy in 2007, he has never gone back on the medication. This is called a functional cure. Timothy may have some virus hidden in his body but he remains off therapy; cured.


Henrich, starting a new research project, was interested in how Timothy’s cure worked. He wanted to understand how HIV hides in the body. Even if a person has been on antiviral therapy for decades with no detectable virus in their blood, once they stop taking drugs, the virus will return. Henrich wondered what role the bone marrow transplant Timothy received played in his cure. To test this he analyzed samples from two men who, like Brown, had cancer and HIV. Unlike Timothy, the bone marrow transplants they received were not CCR5Δ32 and therefore not resistant to HIV. Henrich wasn’t trying to cure anyone. So imagine his surprise when he found the samples he analyzed contained no hidden HIV. The results were announced at the AIDS 2012 conference to an excited crowd. After careful consideration, the team decided to take the two men, now named the Boston patients, off antiviral drugs. Could they, Henrich wondered, control the virus on their own just like Timothy?


The early results were promising. The virus seemed to be held at bay.  The news was unprecedented and undeniably exciting. So it was a blow to learn this week that just 4-8 months after stopping therapy the virus came back. The Boston patients weren’t protected by the bone marrow transplants.


The news is disappointing-especially for these two men who may have briefly dreamed of a life without antiviral drugs. But for HIV research, the news is not a crushing blow; instead the returning virus gives us a new clue about how to cure the infection.


The news isn’t discouraging because bone marrow transplants were never the answer to curing HIV. Bone marrow transplants are dangerous procedures. Approximately 30% of people receiving a transplant from a donor do not survive. No researcher would give a person living with HIV a bone marrow transplant unless it was needed to treat their cancer. The Boston patients were never the answer to curing HIV. Instead, they’re the signposts on the path. Henrich wanted to know what role a bone marrow transplant played in Timothy Brown’s cure. We now can postulate that it wasn’t the transplant alone. This in itself is valuable. It rouses us to further support therapies based on genetic resistance to HIV. The rebounding virus inside these two men tells us the extent of how HIV hides in the body. It reveals the importance of pursuing gene therapy for HIV. Multiple clinical trials are looking at how to use gene therapy to create an immune system that makes the cells in the body look like CCR5Δ32-the mutation keeping the virus controlled in Timothy. They deserve our support more now than ever.


Although we never like hearing about a therapy that doesn’t work or when a virus returns, these cases tell us that when pursuing a cure, we are on the right path.

20 Responses to “The Rise and Fall of the Boston Patients”

  1. MADAM VICKY Reply | Permalink

    I have been suffering hardship from HIV/AIDS since 7yrs now, and i happen to have 2 kids for my husband, and now we cannot proceed to have another kids all because of my disease and now i have do all what a human like i and my husband can do just to get my disease healed, i have went to several places to seek for help not even one person could ever help, until i melt a comment on the daily news paper that was commented by Desmond about how this powerful traditional doctor help him get cured of the disease (HIV-AIDS) " my fellow beloved" i firstly taught having a help from a spiritual traditional healer was a wrong idea, but i think of these, will i continue to stress on these disease all day when i have someone to help me save my life?" so i gather all my faiths and put in all interest to contact him through his Email address at , so after i have mailed him of helping get my disease cured, he respond to me fast as possible that i should not be afraid, that he is a truthful and powerful doctor which i firstly claimed him to be. So after all set has been done, he promise me that i will be healed but on a condition that i provide him some items and obeyed all his oracle said. I did all by accepting his oracles fact and only to see that after some weeks of taking his herbal medicine i notice some changes in my body system and i went for check up the day he ask me to go for check up to confirm if the sickness was still there,to my greatest surprise i could not find any sickness in my body i was first shocked and later arise to be the happiest woman on earth after i have concluded my final test on the hospital by my doctor that i am now HIV- Negative. My papers for check are with me and now i am happy and glad for his miraculous help and power.
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  4. Stella Lucas Reply | Permalink

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  5. Rea Rivera Reply | Permalink

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  9. veronica adams Reply | Permalink

    Hello readers,I am mrs adams veronica,I am from london united kingdom,I was an HIV-AIDS patient and I got it from cheating on my husband,It was sort of a payback,but a week later I was told by a friend that the person who I cheated with had HIV-AIDS and did not tell me,I was so stupid by not protecting myself,I thought since he was an old school friend he was trustworthy,But I was wrong,I cried and cried,Two days later, I got a phone call from my friend and she told me about a person who is known by another friend, who can
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  10. Jerry Wayne Reply | Permalink


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  11. Sarah Anderson Reply | Permalink

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  12. katty Reply | Permalink

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  13. mandy missy Reply | Permalink

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  14. Leon Hobbit Reply | Permalink

    Hello to you all out there reading this testimonial of mine, i am Leon Hobbit, from Cleveland, Ohio, USA. I was infected with herpes virus for over six months, i was not myself, until i was on the internet searching for instant remedy. So luckily, i was reading a testimonial of a client who was cured of herpes too by the amazing spell caster named Dr. Okija, an ancient spell doctor from West Africa. I contacted him by email, and within 48hours, my herpes disease was cured up. All thanks to the superb Dr. Okija for his amazing healing spell. You can get in contact with him now by email:
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  15. william jackson Reply | Permalink

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  16. Judy-may Bourbon Reply | Permalink

    Am Judymay Bourbon. I have been suffering from (HERPES) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr IDEMUDIAN and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr IDEMUDIAN telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr IDEMUDIAN on; ( ) or call +2348068540264 for assistance. sir i am indeed grateful for the help i will forever recommend you to my friends!!

  17. Christabella Cooks Reply | Permalink

    Greetings to the general public, i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Dr West. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor West cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email that was listed on the comment ( ) i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you Dr West God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have any problem Email:


    1. HIV/AIDS
    2. HERPES
    3. CANCER
    4. ALS

  18. Ella Philip Reply | Permalink

    Herpes cure the great Herbalist man is here, My names is ella I want to use this opportunity to thank a great man DR.fara For what he has done for me i was diagnosed of genital herpes almost lost my life if not for a friend of mine who introduced me to DR.fara through his email ( so i contacted him and he told me that he has the power to cure me if only i will obey his rules and regulations i deliberately said i should give it a try so i told him i was willing do anything and he told me to provide some items for the spell of which i cold not get the items so i paid some amount of money to acquire the items for my cure he later ask me to go for medical checkup in any hospital or clinic and i went for the checkup and to my greatest surprise that i was cured totally unity to tell everyone that DR.fara has the power to cure u if only u will believe him just contact him on email at: or call him on +2348054265852
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  19. tanisha cooke Reply | Permalink


    here is my

    I just got diagnosed with HSV1, and reading this actually made me feel like crawling and crying like a baby. The outbreak I have right now is genital and in my throat and mouth, I talked to the doctor who did the blood test on me and said over time that it would eventually get much better. She said that what I’m having is a massive outbreak and is unusual, but that it may be due to the fact that I stressed myself out over it so much. She also told me even though I have it in the genital area that It doesnt mean that I needed “private to private” contact to acquire it. But this did make me feel a whole lot better about the whole situation. For anyone else to has HSV1 after all this stress and pains am passing and the doctor saying all such of crap i was not convince by his Theory so i decided to go on the internet and saw this comments by amanda who testify about how she get cured by root and herbs by DOCTOR UWAWA, when i first bump into it i didn't believe the comments at first so i decided to confront her on Facebook and really know what and how did it work because my doctor told me there is no cure for herpes, so i really contacted doctor Uwawa, he responded in A minute the only thing he ever ask for was just the items of which he will use to prepare for the herbs, after all this he send the herbs through courier Services, within a week i was cure just like that without no struggle or stress, if you are out there in need of cure contact him with his email address,

  20. Patrick Adams Reply | Permalink

    I can’t believe this. A great testimony that i must share to all HERPES SIMPLEX VIRUS patient in the world i never believed that their could be any complete cure for Herpes or any cure for herpes,i saw people’s testimony on blog sites of how Dr SUKU prepare herbal cure and brought them back to life again. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually and i had to leave without the herpes the doctor gave to me. Right now i can tell you that few months now i have not had any pain, and i have just went for text last week and the doctor confirmed that there is no trace of any herpes system on my body. Glory be to God for leading me to this genuine to Dr SUKU I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for herpes that is Not true ,just contact him and get cure from Dr SUKU for your HERPES SIMPLEX VIRUS and you will be free and free forever, Try it and you will not regret it because it truly works. One thing i have come to realize is that you never know how true it is until you try. There is no harm in trying. Remember, delay in treatment leads to death. Here is his email: Contact him and be free from herpes!thank you for you help me to cure my (HERPES SIMPLEX VIRUS) am so grateful to you Dr SUKU make god bless you for you work done.i advice you contact him and get cure on time is real to help you to cure you herpes he have help me too his vie email: or call his Mobil number:+234874839242

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